Anti p kuzmichev biography
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Abstract
A number of epigenetic alterations occur in both the virus and host cellular genomes during human papillomavirus (HPV)-associated carcinogenesis, and investigations of such alterations, including changes in chromatin proteins and histone modifications, have the potential to lead to therapeutic epigenetic reversion. We report here that transformed HPV16 E6/E7-expressing primary human foreskin keratinocytes (HFKs) (E6/E7 cells) demonstrate increased expression of the PRC2 methyltransferase EZH2 at both the mRNA and protein levels but do not exhibit the expected increase in trimethylated H3K27 (H3K27me3) compared to normal keratinocytes. In contrast, these cells show a reduction in global H3K27me3 levels in vitro, as well as upregulation of the KDM6A demethylase. We further show for the first time that transformation with the HPV16 E6 and E7 oncogenes also results in an increase in phosphorylated EZH2 serine 21 (P-EZH2-Ser21), mediated bygd active Akt, and in a downregulation
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To many collectors of nineteenth-century silver and objets de vertu, imperial Russia is the fount of Europe&#;s most exotic work. And even for those who can only dream of its legacy de luxe, mention of Mother Russia immediately triggers thoughts of one name, Fabergé.
Coffeepot marked by Antip Ivanovich Kuzmichev (active c. ), Moscow, c. Stamped &#;Made for Tiffany & Co&#; and scratched &#;&#; on the bottom. Silver gilt and cloisonn&#; enamel; height 7 &#; inches. Photograph by courtesy of Christie&#;s Images.
Tea and coffee service marked by Nichols and Plinke, Saint Petersburg, Silver, parcel gilt; overall length of tray 33 &#; inches. The service was probably made as a wedding gift for Alexander III&#;s cousin Grand Duchess Anastasia Mikhailovna () and Friedrich Franz III (), grand duke of Mecklenburg-Schwerin. Photograph by courtesy of Sotheby&#;s.
Footed tray marked by Ivan Khlebnikov (), Moscow, c. Silver, length approximately 24 inches. Collectio
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By the time of his death, Ivan Khlebnikov had served as official supplier of the Imperial Russian family, the Grand Dukes, and the sovereigns of Denmark, the Netherlands, Serbia and Montenegro. Khlebnikov’s international acclaim stemmed from the numerous exhibitions he participated in, especially those in Vienna () and Moscow () - he won two gold medals at each of these. His company was known for producing decorative silver and enamel work which reinvented traditional Russian style and folk art through originality and a colourful palette. In particular, Khlebnikov was known for immaculate plique-à-jour and cloisonné enamel, and for works produced in the Russian and Modern styles. Nevertheless, Khlebnikov’s output was extremely diverse and also featured the Neo-Baroque, -Rococo and -Classical styles.
Khlebnikov’s remarkable career began in , when this son of a jewellery and diamond merchant opened his own jewellery firm in St Petersburg. His three sons Nikolai, Mikhail and Alexei w