Chein spasm sona van biography
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POEMS
Greetings to you, my desert sisters—
brides of the desert—
warm greetings to you—
a female poet is mixing
with a ladle
the hellish furnace of Der Zor
and your luminous faces
are springing up
one by one
out of the dense smoke—
help me, o muse of the desert,
without you
I can’t
rhyme
the discordant clatter
of these bones—
nor the whisper of the wind
that can be easily tamed into a song
elsewhere
listen!
to my story
buried in silence
greater than God
here—
wasted in the sand
like an eagle’s seed on a stone—
the seed of the most perfect one—
waiting for its hour of bloom
listen! you—
carelessly leaning
against your beloved—
can you listen to my story
without counting the rhymes
of my repeating lines?—
they go back and forth
the wind and the pain ar
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Kingella kingae: Carriage, Transmission, and Disease
SUMMARY
Kingella kingae is a common etiology of pediatric bacteremia and the leading agent of osteomyelitis and septic arthritis in children aged 6 to 36 months. This Gram-negative bacterium is carried asymptomatically in the oropharynx and disseminates by close interpersonal contact. The colonized epithelium is the source of bloodstream invasion and dissemination to distant sites, and certain clones show significant association with bacteremia, osteoarthritis, or endocarditis. Kingella kingae produces an RTX (repeat-in-toxin) toxin with broad-spectrum cytotoxicity that probably facilitates mucosal colonization and persistence of the organism in the bloodstream and deep body tissues. With the exception of patients with endocardial involvement, children with K. kingae diseases often show only mild symptoms and signs, necessitating clinical acumen. The isolation of K. kingae on routine solid media is suboptimal, and det
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Abstract
Skeletal muscle is a major regulator of glycemic control at rest, and glucose utilization increases drastically during exercise. Sustaining a high glucose utilization via glycolysis requires efficient replenishment of NAD+ in the cytosol. Apoptosis-inducing mitochondrion-associated factor 2 (AIFM2) was previously shown to be a NADH oxidoreductase domain–containing flavoprotein that promotes glycolysis for diet and cold-induced thermogenesis. Here, we find that AIFM2 is selectively and highly induced in glycolytic extensor digitorum longus (EDL) muscle during exercise. Overexpression (OE) of AIFM2 in myotubes is sufficient to elevate the NAD+-to-NADH ratio, increasing the glycolytic rate. Thus, OE of AIFM2 in skeletal muscle greatly increases exercise capacity, with increased glucose utilization. Conversely, muscle-specific Aifm2 depletion via in vivo transfection of hairpins against Aifm2 or tamoxifen-inducible haploinsufficiency of Aifm2 in muscles decreases exe